The ten Hacken lab opened at Weill Cornell Medicine NYC in March 2023 and is seeking creative and highly motivated postdoctoral fellows (PhD, MD/PhD or equivalent) experienced in tumor immunology, cancer biology, disease modeling or computational biology. The lab is focused on dissecting the molecular etiology of chronic lymphocytic leukemia (CLL) and Richter’s syndrome (RS) through the generation of innovative in vivo (e.g. CRISPR-based mouse models, patient derived xenografts) and in vitro (e.g. organoids) disease models. Research projects will include but are not limited to: 1) Dissecting the functional relevance of epigenetic drivers in RS transformation; 2) Understanding tumor microenvironmental changes underlying transformation and response to therapy (including through single-cell and spatial technologies); 3) Harnessing RS therapeutic vulnerabilities via novel targeted and immunotherapeutic approaches. The candidate will work within a multidisciplinary and collaborative team of translational scientists, computational biologists and clinicians at the Weill Cornell Medical College, in the Division of Hematology and Medical Oncology and the Meyer Cancer Center. Close collaborators will include (amongst others) Drs. Ari Melnick, Leandro Cerchietti and Dan Landau.
The ten Hacken lab
Dr. Elisa ten Hacken has recently joined the Division of Hematology and Medical Oncology of the Department of Medicine at the Weill Cornell Medical College as Assistant Professor. She has longstanding interest in the pathogenesis of chronic lymphocytic leukemia (with 35 peer-reviewed publications on the topic), with a recent focus on the development of novel mouse models faithful to the genetic complexity of Richter’s syndrome, the yet incurable complication of a proportion of CLL patients, characterized by transformation to aggressive lymphoma. Her lab seeks to understand the molecular mechanisms underlying disease transformation and the associated therapeutic vulnerabilities through in vivo and in vitro modeling and multi-modal single-cell technologies.
Dr. ten Hacken’s lab is located in the heart of the Upper East Side in New York City. Its proximity to the Weill Greenberg Center and the medical college’s hospital will ensure translatability of lab-based discoveries to patient care. The WCM research buildings are embedded in the Tri-Institutional campus, including the Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, and the Rockefeller University, thus providing a rich intellectual and collaborative environment.
Job Requirements
Minimum qualifications
- PhD degree in immunology, cancer biology/pharmacology, bioinformatics or related fields;
- For experimental postdocs: expertise in mouse modeling, cellular and molecular biology, flow cytometry will be favorably considered;
- For computational postdocs: experience with single-cell analytics will be favorably considered;
- Ability to think and work independently, in a collaborative environment;
- Strong interpersonal skills and a track record of collaborative work in multidisciplinary research environments;
- Mastery of written and spoken English.
Application process
Interested applicants should send the following materials by email to Dr. Elisa ten Hacken [email: elt4010@med.cornell.edu]
- CV (including list of publications and technical/computational skills);
- Names and contact information of at least 2 references;
- Preferred start date.
Application deadline: the position/s will be open until filled.
Contact
- Medicine