We are seeking an exceptional and motivated Postdoctoral Associate to join our research program investigating the molecular mechanisms of gating in HCN ion channels and how channel dysfunction contributes to neurological disorders such as epilepsy. Ion channels are key players in many physiological processes and their function is tightly regulated. We aim to understand how ion channels work at the molecular level to meet extremely versatile cellular needs.
See our recent work:
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
Kim, E.D., Wu, X., Lee, S., Tibbs, GR., Cunnningham, KP., Di Zanni, E, Perez, Ma., Goldstein, PA., Accardi A., Larsson PH., Nimigean, CM.Nature 632, 451–459 (2024).
Our laboratory, located within the Department of Anesthesiology at Weill Cornell Medicine on the Upper East Side of Manhattan, combines cutting-edge biochemical, biophysical, and structural approaches to understand ion channel function at the molecular level. This position offers the opportunity to lead innovative research projects aimed at uncovering how HCN channel regulation shapes neuronal excitability and disease.
Weill Cornell Medicine offers an exceptional benefits package, including comprehensive health, dental, and vision insurance, plus subsidized housing in one of the world’s most exciting cities. Under Dr. Nimigean’s mentorship, you’ll thrive in a collaborative environment designed to launch the next generation of scientific leaders.
Job Description:
Develop a research project related to elucidation of the mechanism of gating in HCN channels and how channel dysfunction may contribute to diseases such as epilepsy.
As a Postdoctoral Associate, you will be working on a project related to the mechanism of gating in HCN ion channels and how channel dysfunction may contribute to diseases such as epilepsy. You will be responsible for the following:
- Conduct the research independently and/or collaboratively with colleagues to ensure all experiments are appropriately conducted following Lab, Department, and College policies and procedures.
- Designing, organizing, and carrying out experiments using established protocols, and sometimes adapting to and designing new protocols.
- Collect, prepare, and analyze research data. This may include keeping a detailed notebook summarizing experiments and recording research data and/or maintaining a computer database of the research data.
- Tabulate data for presentations and use graphics and statistical software to analyze and present data.
- Participate in abstract and article preparation with the Principal Investigator, publish results in research journals, and present findings at conferences.
- Assist the Principal Investigator in applying for fellowship, grant, and scholarship support, as requested.
- Assume general responsibility for scientific operations of the laboratory, including training and supervising interns, students, and other laboratory personnel, as necessary.
Minimum Qualifications:
A PhD (or about to obtain one) in Biochemistry, Biophysics, Structural Biology, or related fields
- Letter of recommendation
Preferred Qualifications:
- We welcome applications from enthusiastic and motivated individuals with a PhD (or about to obtain one) in Biochemistry, Biophysics, Structural Biology, or related fields with a strong interest in ion channel structure-function.
- Strong background in structural biology and in biochemistry/biophysics with particular strengths in functional assays of ion channels such as electrophysiology.
- Self-motivated, work independently, and possess excellent communication skills
Application Process:
To apply, please send your current CV to: crn2002@med.cornell.edu. Please include the names of three references able to comment on technical laboratory skills, scientific independence, and creativity.
- For informal enquiries prior to applying, please do not hesitate to contact me: crn2002@med.cornell.edu.
Commitment to Diversity
Weill Cornell Medicine is committed to fostering a culture of diversity and inclusion among our faculty, staff, and students. We seek out individuals with a diverse range of backgrounds and experiences, and we work to create programs that support both our current employees and our recruitment efforts.
EEO Statement
Weill Cornell Medicine welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “any person, any study.” No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law.
Appointment Term:
This is an annual appointment.
Starting Date:
March 1, 2026
Location of Appointment:
The laboratory is located in the Department of Anesthesiology at the main Weill Cornell Medicine campus on the upper east side of Manhattan.
Lab and Department Websites:
The Nimigean Lab website.
Union Membership:
This position is covered under a Collective Bargaining Agreement (CBA) between Weill Cornell Medicine and the International Union, United Automobile, Aerospace, and Agricultural Implement Workers of America (“UAW”), and its Local Union, Weill Cornell Medicine Postdocs United-UAW Local 4100.
Salary:
Postdoctoral research associates are provided an annual salary range of $74,692 to $82,192.
Benefits:
A summary of employee benefits is available on the WCM Human Resources website.
Eligible Visa Categories:
Candidates applying for this position must be eligible to work in the United States and may hold certain eligible visa types consistent with federal regulations including but not limited to a J-1 Exchange visitor visa and the H-1B temporary work visa.
Contact
- Anesthesiology