As a Postdoctoral Associate in the Barisic Lab at Weill Cornell Medicine, you will work on projects focused on how chromatin remodeling complexes and 3D genome organization regulate cell differentiation and drive malignant transformation, with a focus on blood cancer. This role will lead computational and statistical analysis of large-scale functional genomics datasets (e.g., single-cell multi-omics, chromatin accessibility, transcriptional profiling, 3D genome assays) generated from genetically engineered mouse models and human samples, and will integrate these analyses with mechanistic experimental studies in close collaboration with wet-lab scientists.
You will be responsible for the following:
- Conduct the research independently and/or collaboratively with colleagues to ensure all work is appropriately conducted following Lab, Department, and College policies and procedures.
- Design, organize, and carry out computational analyses using established pipelines, and adapt and develop new methods and workflows as needed (including reproducible code, version control, and documented analysis).
- Collect, curate, and analyze research data, including maintaining well-annotated computational notebooks and/or databases that track datasets, parameters, and analysis outputs.
- Participate in abstract and manuscript preparation with the Principal Investigator; publish results in peer-reviewed journals and present findings at scientific conferences.
- Assist the Principal Investigator in applying for fellowship, grant, and scholarship support, as requested (including preliminary analyses, figures, and methods text).
- Assume general responsibility for scientific operations related to computational research in the laboratory, including training and supervising interns, students, and other laboratory personnel in best practices for data analysis and reproducibility, as necessary.
Minimum Qualifications:
- PhD (or equivalent) in computational biology, bioinformatics, genomics, biostatistics, computer science, or a related quantitative field
- Demonstrated experience analyzing large-scale genomic datasets; experience with single-cell and/or chromatin-focused data strongly preferred
- Proficiency in at least one scientific programming language (e.g., Python or R)
- Strong communication skills, ability to work independently, and a collaborative, team-oriented approach
Preferred Qualifications:
- Prior experience with single-cell genomics and multi-omics data (e.g., scRNA-seq, scATAC-seq, Multiome, CITE-seq/DOGMA-seq), including QC, integration, and differential analysis.
- Experience analyzing chromatin and bulk genomics datasets (e.g., ATAC-seq, CUT&Tag/CUT&RUN/ChIP-seq) and performing motif/TF activity analyses.
- Familiarity with 3D genome / chromatin architecture data (e.g., Hi-C, Micro-C), including contact matrix analysis, compartment/TAD/loop calling, and visualization.
- Strong statistical modeling skills (e.g., generalized linear models, mixed models, Bayesian methods, or machine learning) applied to high-dimensional biological data.
- Proven ability to build reproducible, well-documented.
- Prior experience with cancer genomics and/or hematologic malignancies; familiarity with clonal evolution concepts and analysis frameworks is a plus.
- Demonstrated track record of first-author publications and/or evidence of leading analysis from raw data to figures and manuscripts.
Application Process:
Please contact directly Dr. Darko Barisic at dab2078@med.cornell.edu
Commitment to Diversity
Weill Cornell Medicine is committed to fostering a culture of diversity and inclusion among our faculty, staff, and students. We seek out individuals with a diverse range of backgrounds and experiences, and we work to create programs that support both our current employees and our recruitment efforts.
EEO Statement
Weill Cornell Medicine welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “any person, any study.” No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law.
Appointment Term:
Length of time of the appointment is 1 year with an option to be reappointed.
Starting Date:
Starting date is flexible (as soon as possible).
Location of Appointment:
This is an in-person position, Weill Cornell Medicine – Belfer Research Building.
Lab and Department Websites:
https://medicine.weill.cornell.edu/
Salary:
$74,692.00
Benefits:
A summary of employee benefits can be found on the WCM Human Resources website.
Visa Options:
Candidates applying for this position could be eligible for a J-1 Exchange visitor visa and the H-1B temporary worker visa.
Union Membership:
This position is covered under a Collective Bargaining Agreement (CBA) between Weill Cornell Medicine and the International Union, United Automobile, Aerospace, and Agricultural Implement Workers of America (“UAW”), and its Local Union, Weill Cornell Medicine Postdocs United-UAW Local 4100.
Contact
- Medicine