Pharmacology/toxicology awards support career development activities of scientists embarking on research that integrates information on molecular or cellular mechanisms of action with information on the effects of an agent observed in an intact organism, in experimental animal or clinical studies or both.
Highest priority will be given to applicants whose research will attempt to integrate information on a drug or chemical’s mechanism of action at the molecular or cellular level with a drug’s effect in a human or laboratory animal. Applicants should describe the significance of a hypothesis being tested in the context of potential influences of biochemical, physiological, behavioral, or social systems.
These awards intend to encourage training to apply the perspective of molecular, cell, and systems biology to pharmacology and toxicology research. Their scope includes basic drug action studies, detection of cellular responses to drugs at the gene level that create opportunities to optimize individualized drug therapy, and the corresponding evaluation of pharmaceuticals in human and clinical populations.