We are seeking a motivated postdoctoral scientist to investigate how neurovascular dysfunction contributes to the pathogenesis of Alzheimer’s disease (AD) and vascular dementia. The research integrates in vivo cerebrovascular physiology, behavioral assessments, and cellular and molecular approaches using mouse models of amyloid pathology, tauopathy, and APOE-associated disease risk, including Tg2576, 5xFAD, PS19, and APOE3/4-targeted replacement mice. The successful candidate will perform cranial window surgery over the somatosensory cortex, measure cerebral blood flow using various tools (laser speckle imaging, laser Doppler flowmetry, multiphoton microscope, and MRI), conduct behavioral studies, and collect tissues for downstream analyses. Responsibilities will also include maintaining mouse colonies, organizing a tissue biorepository, preparing samples for amyloid-β, tau, and ApoE measurements, and sectioning tissues using a vibratome and cryostat. Additional experiments will involve immunohistochemistry, RNAscope, and light and confocal microscopy. Prior experience with in vivo animal surgery, particularly cranial window preparation, is preferred; training will be provided. Experience assessing reactive oxygen species, nitric oxide, and neuroinflammation is desirable, as is familiarity with computational approaches for analyzing spatial and other omics datasets, including gene co-expression and pathway analyses. The postdoctoral scientist will maintain detailed, accurate records of experiments and results and contribute to laboratory operations, including mouse and chemical inventories, supply ordering, and instrument maintenance. We welcome candidates with strong organizational skills, scientific curiosity, and an interest in collaborative research at the intersection of cerebrovascular biology and neurodegeneration.
The postdoc will be responsible for the following:
- Conduct the research independently and/or collaboratively with colleagues to ensure all experiments are appropriately conducted following Lab, Department, and College policies and procedures.
- Designing, organizing, and carrying out experiments using established protocols, and sometimes adapting to and designing new protocols.
- Collect, prepare, and analyze research data. This may include keeping a detailed notebook summarizing experiments and recording research data and/or maintaining a computer database of the research data.
- Tabulate data for presentations and use graphics and statistical software to analyze and present data.
- Participate in abstract and article preparation with the Principal Investigator, publish results in research journals, and present findings at conferences.
- Assist the Principal Investigator in applying for fellowship, grant, and scholarship support, as requested.
- Assume general responsibility for scientific operations of the laboratory, including training and supervising interns, students, and other laboratory personnel, as necessary.
Minimum Qualifications:
-PhD degree
Application Process:
Please submit a cover letter, CV and 2-3 letters of recommendation to Dr. Park at
Commitment to Diversity
Weill Cornell Medicine is committed to fostering a culture of diversity and inclusion among our faculty, staff, and students. We seek out individuals with a diverse range of backgrounds and experiences, and we work to create programs that support both our current employees and our recruitment efforts.
EEO Statement
Weill Cornell Medicine welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “any person, any study.” No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law.
Appointment Term:
This is a one-year appointment with the potential for reappointment.
Starting Date:
2/1/2027
Location of Appointment:
Feil Research Building
407 East 61st Street
New York, NY 10065
Lab and Department Websites:
https://brainandmind.weill.cornell.edu/
https://brainandmind.weill.cornell.edu/bmri-neurovascular-pathologies-and-neurodegeneration
Salary:
$76,000
Benefits:
A summary of employee benefits can be found on the WCM Human Resources website.
Visa Options:
Candidates applying for this position could be eligible for a J-1 Exchange visitor visa and the H-1B temporary worker visa.
Union Membership:
This position is covered under a Collective Bargaining Agreement (CBA) between Weill Cornell Medicine and the International Union, United Automobile, Aerospace, and Agricultural Implement Workers of America (“UAW”), and its Local Union, Weill Cornell Medicine Postdocs United-UAW Local 4100.
Contact
- Neuroscience