The postdoctoral scientist will be interrogating the role of lipid metabolism in Alzheimer’s disease mouse models and human cell models. Duties will include mouse colony maintenance, behavioral studies and tissue harvest from multiple mouse models of Alzheimer’s disease including APP, BIN1, ACSL6, PICALM and ABCA7. They will be responsible for organizing biorepository of tissues and preparing tissue samples for lipidomic analyses as well using cryosectioning. The postdoc will also perform bench experiments including but not limited to ICC, RNAscope, exosome isolation. Prior experience is preferred, but training will be provided. Expertise in induced pluripotent stem cells to model lipid deficits in differentiated neurons, microglia and astrocytes is preferred. They will also assist in determining fluid biomarkers in human and mouse biospecimens. The postdoc will keep a lab notebook with detailed records of all experiments and results as well as assist with mouse inventory, chemical inventory, ordering inventory and instrument maintenance. Experience with computational methods for spatial and -omics co-expression and pathway analyses is preferred.
They will be responsible for the following:
- Conduct the research independently and/or collaboratively with colleagues to ensure all experiments are appropriately conducted following Lab, Department, and College policies and procedures.
- Designing, organizing, and carrying out experiments using established protocols, and sometimes adapting to and designing new protocols.
- Collect, prepare, and analyze research data. This includes keeping a detailed notebook summarizing experiments and recording research data and/or maintaining a computer database of the research data.
- Tabulate data for presentations and use graphics and statistical software to analyze and present data.
- Participate in abstract and article preparation with the Principal Investigator, publish results in research journals, and present findings at conferences.
- Assist the Principal Investigator in applying for fellowship, grant, and scholarship support, as requested.
- Assume general responsibility for scientific operations of the laboratory, including training and supervising interns, students, and other laboratory personnel, as necessary.
Minimum Qualifications:
Education: PhD
Prior experience:
Bench work including or similar to:
biochemical techniques including western blot and immunoprecipitiation,
extracellular vesicle isolation
plate assays,
ICC, IHC or RNAscope,
microscopy,
mouse behavior and tissue collection as well as colony maintenance experience
and cell culture.
Must work well in a collaborative environment with other scientists at all levels of training as well as core-facilities and shared instrumentation
2 letters of recommendation or referee contacts sent directly to Dr. McIntire
Preferred Qualifications:
Computational analysis of -omics data (spatial -omics preferred) using R or python
Mass spectrometry or HPLC
Application Process:
Please submit a cover letter, CV and 2 letters of recommendation directly to Dr. McIntire at lbm7002@med.cornell.edu
Commitment to Diversity
Weill Cornell Medicine is committed to fostering a culture of diversity and inclusion among our faculty, staff, and students. We seek out individuals with a diverse range of backgrounds and experiences, and we work to create programs that support both our current employees and our recruitment efforts.
EEO Statement
Weill Cornell Medicine welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “any person, any study.” No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law.
Appointment Term:
1 year with possibility of reappointment
Starting Date:
10/1/2026
Location of Appointment:
Feil Research Building 407 E. 61st Street, RR230
Lab and Department Websites:
https://radiology.weill.cornell.edu/research/brain-health-imaging-institute-bhii
Salary:
$75,812 - $86,535
Benefits:
A summary of employee benefits can be found on the WCM Human Resources website.
Visa Options:
Candidates applying for this position could be eligible for a J-1 Exchange visitor visa and the H-1B temporary worker visa.
Union Membership:
This position is covered under a Collective Bargaining Agreement (CBA) between Weill Cornell Medicine and the International Union, United Automobile, Aerospace, and Agricultural Implement Workers of America (“UAW”), and its Local Union, Weill Cornell Medicine Postdocs United-UAW Local 4100.
Contact
- Radiology