Postdoctoral Associate in Biochemistry & Biophysics

The Lange Lab at Weill Cornell Medicine in New York City invites applications for a postdoctoral position. Our research addresses fundamental questions about how ubiquitin signals are interpreted to regulate intracellular transport and how disruption of these processes contributes to neurodegeneration and other diseases.

We are a multi-disciplinary lab using biochemical, structural, biophysical, and proteomics approaches to uncover fundamental biological mechanisms. Additional information about the lab and its research goals can be found at https://sven-lange.xyz.

We welcome applications from recent PhD graduates and candidates who expect to complete their PhD before the position begins. We are particularly interested in applicants with experience in one or more of the following areas: single-molecule TIRF microscopy, structural biology, protein biochemistry and proteomics, or advanced cell culture techniques.

The successful candidate will work closely with Dr. Lange to develop and lead an independent research project within the laboratory’s broader research program. The postdoctoral researcher will:

• Conduct the research independently and/or collaboratively with colleagues to ensure all experiments are appropriately conducted following Lab, Department, and College policies and procedures.
• Apply established experimental methods and develop or adapt protocols as needed. Relevant approaches may include protein expression and purification, biochemical characterization of protein interactions, cell culture, quantitative immunofluorescence, single-molecule microscopy, structural and computational biology, and proteomics.
• Collect, prepare, and analyze research data. This may include keeping a detailed notebook summarizing experiments and recording research data and/or maintaining a computer database of the research data.
• Communicate findings through laboratory and departmental presentations, scientific conferences, peer-reviewed publications, and other appropriate venues.
• Contribute to the preparation of manuscripts, abstracts, fellowship applications, grants, and other scientific materials.
• Participate in the collaborative scientific environment of the laboratory, including mentoring students and supporting shared laboratory activities as appropriate.

Minimum Qualifications: 

• A PhD in biochemistry, structural biology, biophysics, cell biology, molecular biology, or a related field, completed by the position’s start date.
• Demonstrated ability to conduct rigorous research independently and within a team
• Strong analytical, problem-solving, organizational, and time-management skills.
• Strong oral and written communication skills
• Enthusiasm for fundamental biological research and a commitment to a constructive, collaborative laboratory environment.

Preferred Qualifications: 

Experience in one or more of the following areas is preferred: 

• Quantitative optical microscopy, such as single-molecule TIRF microscopy.
• Structural biology, such as single-particle cryo-electron microscopy.
• Protein expression, purification, and biochemical characterization.
• Proteomics and protein pulldown workflows.
• Advanced cell culture methods, such as CRISPR-based genome editing.
• Computational analysis of imaging, structural, biochemical, or proteomics data.

Candidates are not expected to have experience in all of these areas. Training in complementary techniques will be available. 

Application Process: 

To apply, please send the following directly to Dr. Sven Lange at sml4006 at med.cornell.edu 

• A current curriculum vitae.
• A summary of your PhD research of no more than 300 words.
• A cover letter of no more than 500 words describing your interest in the Lange Lab, your relevant experience, and preliminary ideas for research questions or directions you might pursue.
• The names and contact information of two individuals who have agreed to serve as references.

Commitment to Diversity 

Weill Cornell Medicine is committed to fostering a culture of diversity and inclusion among our faculty, staff, and students. We seek out individuals with a diverse range of backgrounds and experiences, and we work to create programs that support both our current employees and our recruitment efforts.

EEO Statement 

Weill Cornell Medicine welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “any person, any study.” No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law. 

Appointment Term: 

Initial appointment term is for 1 year; eligibility for annual reappointment is contingent on both performance and funding availability.

Starting Date:

Spring 2027. Applications will be reviewed on a rolling basis until the position is filled.

Location of Appointment:

1300 York Avenue, New York, NY 10065

Lab and Department Websites: 

The Lange lab website can be found here.

The Department of Biochemistry & Biophysics website can be found here.

Salary: 

Salary starts at $75,812 per annum with potential for adjustment based on the Postdoc Union’s collective bargaining agreement.

Benefits:

A summary of employee benefits can be found on the WCM Human Resources website.

Visa Options:

Candidates applying for this position could be eligible for a J-1 Exchange visitor visa and the H-1B temporary worker visa.

Union Membership:

This position is covered under a Collective Bargaining Agreement (CBA) between Weill Cornell Medicine and the International Union, United Automobile, Aerospace, and Agricultural Implement Workers of America (“UAW”), and its Local Union, Weill Cornell Medicine Postdocs United-UAW Local 4100.