Postdoctoral Positions in Wen Laboratory

Wen Laboratory (2-3 openings)

Background:

Cell fate is determined by gene expression, which is further determined by the modifications of chromatin that regulate access to DNA. Chromatin that comprises 147bp of DNA bound to two copies of histones H2A, H2B, H3 and H4, provides a central framework for epigenetics, the inherited phenotypes governed by differences that cannot be explained by the differences in DNA sequence. Our laboratory has been focused on the functional dissection of histone variant H3.3 for reprogramming and development. We developed a low-input ChIP-seq technology using as few as 100 cells, and have successfully profiled the dynamic H3.3 landscapes on preimplantation embryos. Current research areas include: (1) defining the contribution of H3.3 for pluripotency using induced pluripotent stem cells (iPSCs), (2) epigenetic mechanisms for zygotic genome activation in mouse and human embryos, and (3) epigenetic reprogramming mediated by oocytes.

How to Apply:

Send resume/CV, cover letter, and three reference contacts to Dr. Duancheng Wen (duw2001@med.cornell.edu)

Job Requirements

  • Required skills and experience: epigenetics, NGS technology, gene editing, and pluripotent stem cells
  • Required educational background: PhD in epigenetics, stem cells, embryology

Contact

Duancheng Wen, PhD

Office of Postdoctoral Affairs 1300 York Ave, Suite A-139 New York, NY 10065 Phone: