Postdoctoral Positions in the Schwer and Shuman Labs

Two postdoctoral positions are available to pursue studies of RNA 3’-processing and transcription termination and of phosphate homeostasis in fission yeast in the laboratories of Prof. Beate Schwer (Weill Cornell Medical College) and Prof. Stewart Shuman (Memorial Sloan Kettering Cancer Center).

Topics of acute interest include: (i) lncRNA-mediated transcriptional interference; (ii) metabolite control of RNA 3’-processing/termination by inositol pyrophosphates; (iii) transcription control of phosphate homeostasis; and (iv) cellular responses and adaptations of fission yeast to phosphate starvation.

Representative publications:

  1. Shuman, S. (2020) Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis. Nucleic Acids Res. 48:8243-8254.
  2. Sanchez, A.M., Garg, A., Shuman, S. and Schwer, B. (2019) Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination. Nucleic Acids Res 47, 8452-8469.
  3. Schwer B, Garg A, Jacewicz A and Shuman S. (2021) Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factors Seb1. Proc Natl Acad Sci USA118, e2108105118
  4. Benjamin, B., Garg, A., Jork, N., Jessen, HJ., Schwer, B. and Shuman, S. (2022) Activities and structure-function analysis of fission yeast inositol pyrophosphate (IPP) kinase-pyrophosphatase Asp1 and its impact on regulation of pho1 gene expression. mBio13: e0103422.

Job Requirements

Our multi-modal approach to the topics mentioned above integrates fission yeast genetics, protein and RNA biochemistry, transcription profiling, and structural biology. Candidates for the positions will have a PhD and experience in one or more of these areas.

Interested candidates please forward CV and contact information for 2 referees to:

Dr. Beate Schwer, Weill Cornell Medical College: bschwer@med.cornell.edu

Dr. Stewart Shuman, Memorial Sloan Kettering Cancer Center:  shumans@mskcc.org

 

The salary range for the positions is: $58,500 – $66,538.

Weill Cornell Medicine provides the above salary range in compliance with the New York City law on Salary Transparency in Job Advertisements. The salary range listed is for full‐time employment not including bonuses, clinical incentive compensation, or benefits. Actual salaries depend on a variety of factors including but not limited to internal equity, specialty, training, and hospital/community needs. The above salary range for New York City based roles represents WCM’s good faith and reasonable estimate of possible compensation at the time of posting.

Contact

Beate Schwer, Ph.D.

Office of Postdoctoral Affairs 1300 York Ave, Suite A-139 New York, NY 10065 Phone: