Our Lab investigates the critical signaling and transcriptional events that mediate the activation of degenerative process driven by lipofuscin in the retina. We use cell culture, mice and human donor retinas to understand how buildups in lysosomes may initially affect cytosolic and endoplasmic reticulum (ER) stress and how these can lead to regulated necrosis and tissue atrophy. Current projects in this are built on work published in Pan et al. (2021) PNAS, PMID: 34782457. We are also studying one of the most fundamental problems in the lysosomal storage and aging fields: how to get rid of lipofuscins and other indigestible waste-materials, to rescue and rejuvenize cells. We are studying the mechanisms of cell clearance, testing potential therapeutic drugs in animal models and developing formulations for their efficient administration. Current results in this area are built on work published in Nociari et al. (2014) PNAS, PMID: 24706818.
Our lab is equipped with state-of the art microscopes setup for live-cell imaging. We are also part of an exceptional academic environment with opportunities for interdisciplinary and collaborative work within Weill-Cornell/Purdue University, Rockefeller University, and Memorial Sloan Kettering Cancer Center. This position offers competitive benefits and access to subsidized Cornell housing in Manhattan and Roosevelt Island.
Applications are welcomed from highly motivated, self-driven, organized individuals. The ideal candidate will have experience in cell culture, animal models and/or molecular biology techniques.
To apply, please email a cover letter and CV to Dr. Marcelo Nociari. Email: email@example.com