Postdoctoral Position Available in Tumor Immunology

Applicant will conduct research aimed at studying the anti-tumor immune response in mouse models and in patients. He/she will perform in vitro and in vivo experiments testing the recognition of cancer cells by T cells, and how this is modulated by radiation therapy. In particular, we are studying the effects of radiation on the immune-peptidome that is presented by cancer cells, including mutational neoantigens, and neoantigens generated by post-translational modifications and alternative splicing. We are developing an innovative immune monitoring platform based on the use of patient-derived tumor organoids. He/she will work within an interdisciplinary group working on different aspects of interaction between radiation and the immune system that span basic to translational research.  Applicant will have the opportunity to present her/his results at departmental and institutional meetings, and at national and international meetings.

Job Requirements

The ideal candidate has recently obtained a Ph.D. in an immunology-related field and has practical experience and excellent skills in immunological assays, molecular biology, and mouse models of cancer. Experience with cell culture, protein biochemistry, multi-color flow cytometry, gene arrays, and gene knockdown techniques, are highly desirable. He/she should be highly motivated, know how to work independently as well as collaborate within a team and interact with collaborators, be willing to learn new techniques and new concepts. Fluent spoken and written English is required.

About the Employer

The applicant will find a fertile and stimulating intellectual environment at Weill Cornell Medical College in New York City. He/she will join the lab of Dr. Sandra Demaria, which is at the center of the newly established program of radiation and immunity. The program is based on a bench to bedside and back approach and aimed at finding novel treatment strategies in pre-clinical models of cancer and translate them in the clinic. Dr. Demaria’s group has multiple national and international collaborations and is at the forefront of the exciting and thriving field of cancer immunotherapy and radiotherapy.

If interested send your cv and list of referees to:

Dr. Sandra Demaria
E-mail:  szd3005@med.cornell.edu
https://radiationoncology.weillcornell.org/research/demaria-lab

Representative Publications 
Pilones KA, Charpentier M, Garcia-Martinez E, Daviaud C, Kraynak J, Aryankalayil J, Formenti SC, Demaria S. Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses. Cancer Immunol Res. 2020 Aug;8(8):1054-1063. PMID: 32532811; PMCID: PMC7415682.

 Wennerberg E, Spada S, Rudqvist NP, Lhuillier C, Gruber S, Chen Q, Zhang F, Zhou XK, Gross SS, Formenti SC, Demaria S. CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection. Cancer Immunol Res. 2020 Apr;8(4):465-478. PMID: 32047024; PMCID: PMC7125001.

Lhuillier C, Rudqvist NP, Elemento O, Formenti SC, Demaria S. Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system. Genome Med. 2019 Jun 20;11(1):40. PMID: 31221199; PMCID: PMC6587285.

Formenti SC, Rudqvist NP, Golden E, Cooper B, Wennerberg E, Lhuillier C, Vanpouille-Box C, Friedman K, Ferrari de Andrade L, Wucherpfennig KW, Heguy A, Imai N, Gnjatic S, Emerson RO, Zhou XK, Zhang T, Chachoua A, Demaria S. Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat Med. 2018 Dec;24(12):1845-1851. PMID: 30397353; PMCID: PMC6286242.

Diversity is one of Weill Cornell Medicine’s core values and is essential to achieving excellence in patient care, research, and education. We welcome applications from candidates who share our commitment to fostering a culture of fairness, equity, and belonging. Weill Cornell Medicine is an Equal Employment Opportunity Employer, providing equal employment opportunities to all qualified applicants without regard to race, sex, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, or genetic information.

Contact

Sandra Demaria, M.D.

Office of Postdoctoral Affairs 1300 York Ave, Suite A-139 New York, NY 10065 Phone: