A full-time postdoctoral position is available immediately in the Hochrainer Laboratory in the Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York City, to work on an NIH-funded project that studies the role of protein modifications, with focus on ubiquitination, in adaptation of the brain cell proteome in response to acute ischemic stroke.
Several studies have established that ischemic stroke leads to an immediate and prolonged shut-down of protein synthesis in affected brain cells. As a consequence, these cells have to combat the ischemic stress without the potential of renewal or expansion of the intracellular protein pool, an important aspect that has been largely overlooked. Protein modifications have the power to effectively change a protein’s function or stability, and thus hold promise as an important molecular modulator of ischemic cell fate. The goal of this research project is a) to identify proteins that undergo modifications after ischemia, and b) investigate the impact of these modifications on ischemic cell fate.
This position is open to highly motivated, diligent recent Ph.D. or MD/Ph.D. graduates in neuroscience, molecular biology, cell biology or a related field. Candidates should have strong organizational skills, good command of the English language, effective written and oral communication skills, and be able to provide evidence of research productivity. The applicants should have the ability to think critically, and design and conduct experiments independently and as part of a team.
Preference will be given to individuals with expertise in molecular and cell biology techniques (recombinant DNA technologies, RNA and protein expression analysis, microscopy), protein biochemistry (immunoprecipitation, protein purification), in vitro mammalian cell culture (e.g. neurons, astrocytes, cell lines), and mouse work. Expertise in bioinformatics is a plus.
We are a young and upcoming group embedded in a highly collaborative network of stroke scientists, electrophysiologists and molecular neurobiologists. Cornell University's Weill Cornell Medicine is located in Manhattan, New York, immediately adjacent to the Sloan Kettering Institute and Rockefeller University, and as such offers the exposure to a dynamic and vibrant scientific environment that provides unique and unparalleled research training opportunities, including seminars given by scientific leaders from throughout the world, exposure to diverse research programs, highly sophisticated core facilities, grant writing workshops, career exploration events and professional development workshops. Weill Cornell Medicine provides subsidized housing for eligible Postdocs. Since we are exploring a very new research area, the publications that arise from this project will likely have an important impact on the field.
Interested candidates should send a CV, a brief cover letter summarizing past research and career goals, and the names and contact information of three referees to Dr. Karin Hochrainer; e-mail: email@example.com. More information is available on our website: